The Nucleofill guide

Polynucleotides, explained

Nucleofill is a range of regenerative skin treatments rather than a single product. Here is how it works, what each formulation is for and what to expect, so you arrive at your consultation informed.

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Prefer to talk? Call or text Louise on 07746 515803

What it is

Better skin, not more volume

Nucleofill gels are made from polynucleotides: long chains of the natural building blocks of DNA, purified for aesthetic use. Rather than filling, they improve the quality of the skin itself, so it looks healthier, better hydrated and more resilient. Results develop gradually and look like you.

Fibroblast activity

Fibroblasts maintain your skin and produce its structural components. Polynucleotides are studied for their effect on this activity and on tissue repair.

Hydration

Polynucleotides attract and hold water, supporting the improved hydration reported in aesthetic studies.

Matrix remodelling

Ageing changes collagen, elastin and the skin's supporting matrix. Nucleofill works with these processes rather than adding instant projection.

Repair signalling

Research also explores how polynucleotides influence repair and inflammatory signals, one reason results build over a course.

The range

Choosing your Nucleofill

Each formulation suits a different area and goal. The right one is chosen at your consultation.

The delicate eye area

Nucleofill Eyes

0.75%2ml

The lightest formula, made for thin skin around the eyes. Best for crepey texture, fine lines and a tired look caused by thin skin rather than hollowing.

Facial skin quality

Nucleofill Medium

2%1.5ml

The versatile all-rounder for the face, supporting hydration, texture, fine lines, elasticity and overall skin quality.

Firmness and tissue quality

Nucleofill Strong

2.5%1.5ml

A higher concentration, with treatment centred on elasticity, firmness, texture and visible age-related change.

A higher percentage does not mean a better result. The right product matches your concern and your skin, not simply the strongest.

Under the eyes

A tired look has many causes

Dark or tired-looking eyes are a description, not a diagnosis. Nucleofill Eyes works best where thin, crepey skin is the issue, so we first work out what is behind your concern.

Thin, crepey skin

Fine lines and a delicate, crinkled texture around the eyes.

Often well suited to Nucleofill Eyes

Tear-trough hollowing

A structural hollow where volume has been lost beneath the eye.

May need volume rather than skin quality

Pigment and visible vessels

Darkness from melanin, or blood vessels showing through thin skin.

Needs separate assessment

Puffiness and fat pads

Swelling or prominent fat pads that create shadow and bags.

Assessed before any injectable

Compared

Nucleofill and your other options

Nucleofill and hyaluronic acid boosters

Nucleofill is often grouped with skin boosters such as Profhilo, but it uses polynucleotides rather than hyaluronic acid, so it works differently. Neither is simply better; the choice follows your skin, history and goals.

Nucleofill and dermal filler

Filler restores volume, projection and contour. Nucleofill improves hydration, texture and tissue quality, and isn't designed to reshape features. They are different goals, and many clients benefit from both.

Your treatment

What to expect, and is it right for you?

Your wellbeing comes first. Every treatment begins with a full consultation covering your medical history, medicines, allergies and previous treatments.

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Prefer to talk? Call or text Louise on 07746 515803

What to expect

Gradual, not instantA progressive skin-quality treatment rather than an immediate volumiser. Improvements build over time.
A tailored courseThere is no one-size protocol. Your number of sessions and their spacing are set at consultation, following product guidance.
Longevity variesHow long results last depends on the product, area, your skin, lifestyle and maintenance, so no duration can be guaranteed.
Tracked progressConsistent before-and-after photographs track real change, particularly around the eyes, where lighting can mislead.

Who may not be suitable

We may advise against treatment if you have:

An active infection or skin inflammation in the area
An allergy to fish or salmon-derived products
Pregnancy or breastfeeding
A bleeding disorder, or medicines that affect bleeding
Impaired healing, or relevant immune or systemic disease
An active cold sore, or unexplained skin lesions

Common short-term effects
Redness, swelling, tenderness, bruising, itching and small temporary bumps at the injection sites. These usually settle quickly.

This list is not exhaustive. Your suitability is always confirmed in person.

This guide is general information only. It does not replace individual assessment or manufacturer guidance, and results cannot be guaranteed.

Find your Nucleofill

Book a consultation and Michael will recommend the right product, and the right course, for your skin.

Book a consultation Back to treatments

Prefer to talk? Call or text Louise on 07746 515803